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Since then, the cohort study has contributed to 24 prospective waves of incredibly valuable data collection to gain a better understanding of population health and well-being over time—including MRI and PET imaging, extensive cognitive assessments, physical exams, and blood-based biomarkers at age 70.
Using the MRI data, researchers compared each participant’s brain age to their chronological age, coming up with what’s called a brain-predicted age difference (brain-PAD). Researchers then used brain-PAD scores to determine what biological factors contribute to healthy brain aging.
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